When the Diocletian persecution began, the Prefect Lysias had Cosmas and Damian arrested, and ordered them to recant. They remained constant under torture, in a miraculous manner suffered no injury from water, fire, air, nor on the cross, and were finally beheaded with the sword. Their three brothers, Anthimus, Leontius, and Euprepius died as martyrs with them. The execution took place 27 September, probably in the year 287. At a later date a number of fables grew up about them, connected in part with their relics. The remains of the martyrs were buried in the city of Cyrus in Syria; the Emperor Justinian I (527-565) sumptuously restored the city in their honour. Having been cured of a dangerous illness by the intercession of Cosmas and Damian, Justinian, in gratitude for their aid, rebuilt and adorned their church at Constantinople, and it became a celebrated place of pilgrimage. At Rome Pope Felix IV (526-530) erected a church in their honour, the mosaics of which are still among the most valuable art remains of the city. The Greek Church celebrates the feast of Saints Cosmas and Damian on 1 July, 17 October, and 1 November, and venerates three pairs of saints of the same name and profession. Cosmas and Damian are regarded as the patrons of physicians and surgeons and are sometimes represented with medical emblems. They are invoked in the Canon of the Mass and in the Litany of the Saints.
